T Lymphocytes Are Not Immune
نویسندگان
چکیده
منابع مشابه
Irradiated β-glucan enhances immune response to bacterial infection through CD4 and CD8 T-lymphocytes
Background: &beta-glucans are glucose polymers with a variety of stimulatory effects on the immune system. The objective of this study was to evaluate the immune-enhancing activities of low molecular weight gamma irradiated &beta-glucan (I&beta-g) extracted from Pleurotus ostreatus in response to Pseudomonas aeruginosa infection in rats. Materials and Methods: &beta-glucan (&beta-g) powder was ...
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Regulatory T cells (Treg) that express the transcription factor Foxp3 are enriched within a broad range of murine and human solid tumors. The ontogeny of these Foxp3 Tregs - selective accumulation or proliferation of natural thymus-derived Treg (nTreg) or induced Treg (iTreg) converted in the periphery from naïve T cells - is not known. We used several strains of mice in which Foxp3 and EGFP ar...
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Acute rejection continues to present a major obstacle to successful lung transplantation. Although CD4(+) T lymphocytes are critical for the rejection of some solid organ grafts, the role of CD4(+) T cells in the rejection of lung allografts is largely unknown. In this study, we demonstrate in a novel model of orthotopic vascularized mouse lung transplantation that acute rejection of lung allog...
متن کاملMost murine CD8+ intestinal intraepithelial lymphocytes are partially but not fully activated T cells.
Murine small intestine intraepithelial lymphocytes (IELs) bear properties of both activated and nonactivated T cells, although the significance of that dichotomy remains unclear. In this study, we show that although IELs express CD69 in situ and ex vivo, and have cytotoxic activity ex vivo, most CD8(+) IELs from normal mice are phenotypically similar to naive T cells in that they are CD45RB(hig...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2013
ISSN: 1525-0016
DOI: 10.1038/mt.2013.102